 This paper discusses the development of artificial organelles, AOs, which can be used to treat diseases caused by defective proteins or enzymes. The AOs are designed to mimic the functionality of lysosomes and macrophages, which are both involved in the breakdown of biomolecules. These AOs are made up of polymer-based structures that contain trypsin, an enzyme that breaks down biomolecules. The polymer-based structure allows the AO to respond to changes in pH and salt concentration, which affects its ability to degrade biomolecules. By adjusting these parameters, the AOs can be used to target specific types of diseases. This article was authored by Xiaoying Su, Sylvia Moreno, Suzanne Boy, and others.