 Aging is characterized by chronic inflammation which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. This multifaceted process is driven by the secretion of factors from senescent cells, known as the senescence-associated secretory phenotype, SASP. These factors promote chronic inflammation and can induce senescence in normal cells, further exacerbating the inflammation and creating a vicious cycle. Chronic inflammation also leads to weakened immune function and an inability to clear senescent cells and inflammatory factors, which contributes to the progression of aging. Inflammation has been recognized as an endogenous factor in aging, and its elimination could be a potential strategy for anti-aging. This article was authored by Xia Li, Chen Daoli, Wanying Zhong, and others.