 we conducted a comprehensive literature review to identify potential prognostic biomarker candidates for hepatocellular carcinoma, HCC. We then validated these candidates in three different data sets, including RNA sequencing, microarrays, and gene chip data. We found that 180 out of 318 genes remained significant in Asian patients after multiple testing correction, while none remained significant in Caucasian patients. However, we did find that stage in expression of certain genes such as CEMPH and CDK4 were significantly associated with overall survival. Additionally, we identified KIF18A as the only gene that predicted vascular invasion in both the aphometrics and Illumina data sets. This study helps to eliminate biomarkers with limited capability to predict overall survival or vascular invasion, which can be used to further a fine prognostic biomarker candidates for HCC. This article was authored by Otelia Menihart, Adam Nagy, and Bawlish GYNFFY. We are article.tv, links in the description below.