 This study qualitatively examines the risk and protective factors of cigarette smoking among transgender and gender expansive, TGE, adults through real world exemplars, identifying six major themes of risk and protective factors of smoking among TGE individuals. The findings will inform future community engaged research to develop culturally tailored interventions to reduce smoking prevalence among TGE individuals. This article was authored by Andy SL Tan, Priscilla K. Gazarian, Sabreen Darwish, and others.