Ductal carcinoma in situ (DCIS) simulation - extended results




Rating is available when the video has been rented.
This feature is not available right now. Please try again later.
Published on Dec 20, 2010

This is Video S1 in Macklin et al. (2012).
Paper: http://dx.doi.org/10.1016/j.jtbi.2012...

Agent-based simulation of ductal carcinoma in situ (DCIS), a type of breast cancer that is constrained to growth in the breast duct lumen by a basement membrane. Shown here: a simulation of 45 days' growth in a 1.5 mm length of duct.

The mechanical and population dynamic parameters have been calibrated to patient-specific immunohistochemistry and other histologic measurements.

Dark circles: cell nuclei
Green cells: proliferating cells (Ki-67 positive; S, G2, M, or G1)
Red cells: apoptosis cells (cleaved Caspase-3 positive)
Pale blue cells: quiescent cells (G0)
Dark grey cells: necrotic cells prior to lysis
Debris in centre of duct: necrotic cellular debris
Red dots in centre of duct: clinically-detectable microcalcifications

Method: Agent-based, lattice-free model. Cell velocities determined by balance of adhesive and repulsive forces. Each cell has a phenotypic state governed by stochastic processes derived from nonhomogeneous Poisson processes.

Source: Macklin et al., "Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): From microscopic measurements to macroscopic predictions of clinical progression." J. Theor. Biol., 2012.

Preprint: http://www.MathCancer.org/Publication...
publisher: http://dx.doi.org/10.1016/j.jtbi.2012...

Note: This is an update of the earlier animation at



When autoplay is enabled, a suggested video will automatically play next.

Up next

to add this to Watch Later

Add to

Loading playlists...