 High-dose recombinant human erythropoietin APO has been shown to be beneficial in treating certain injuries such as those to the heart or kidney. However, there is evidence that EPO can cause fibrosis over time, which could lead to further damage in these organs. Therefore, it is important to balance the potential benefit of using EPO against the risk of causing more harm than good. This article was authored by Glenda C. Gobe, Christopher Moray, David Evici, and others.