 SHIFT bases are versatile compounds synthesized from amino and carbonyl compounds, widely used for industrial purposes and exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. They show excellent catalytic activity in various reactions and in the presence of moisture. SHIFT base complexes are useful attributes for their application as catalysts in reactions involving high temperatures. The activity is usually increased by complexation, leading to synthesis of highly active compounds. The influence of certain metals on biological activity and intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behavior. Development of new chemotherapeutic SHIFT bases and their metal complexes is attracting the attention of medicinal chemists and this review compiles examples of promising applied SHIFT bases and their complexes in different areas. This article was authored by Ahmed M. Abu-Dif and Ibrahim M.A. Mohamed. We are article.tv. Links in the description below.