 In this study, researchers examined the differences between children who had mild, moderate, and severe cases of acute respiratory distress syndrome, ARDS. They found that children with more severe cases showed decreased levels of interferon stimulated genes, ISGs, as well as changes in their mononuclear phagocyte transcriptomes and progressive airway neutropathy. Additionally, they discovered that a protein called FOLR3 was highly expressed in children with moderate to severe ARDS. These findings suggest that different inflammatory responses may be responsible for the development of mild, moderate, and severe forms of ARDS. This article was authored by Tim Flairlage, Jeremy Chase Crawford, E. Caitlyn Allen, and others.