 The study examined the preparation of fluconazole-loaded nanospunges, NS, using an emulsion-solvent diffusion method. The NS were characterized by scanning electron microscopy, SEM, failure-transform infrared spectroscopy, FTIR, powder x-ray diffraction, PXRD, and in vitro drug release studies. The NS were found to be discrete, free-flowing nanosized particles with a perforated orange peel-like morphology. The drug-loaded NS showed a prolonged release profile and the kinetic modeling indicated that the best-fitted model was Higuchi. No drug polymer interactions or instability of the drug in the delivery system were observed from FTIR and PXRD studies. This article was authored by Nezia Abbas, Mjad Hussain, Muhammad Asin Hafiz, and others.