 The Rhode Island Department of Correction successfully implemented a statewide vaccination program among incarcerated people and staff working in a prison setting, with 76.4% of sentenced individuals and 68.4% of correctional staff accepting and receiving the vaccine during the initial campaign, and 77.7% of the sentenced population and 69.6% of staff being fully vaccinated four months later. Education and communication likely played an important role in mitigating vaccine refusals. This article was authored by Justin Burke, Matthew Murphy, Kimberly Kane, and others.