 This study investigated the potential mechanisms behind the beneficial effects of olive leaf extract, OLE, on lipid and blood glucose levels in rats. OLE was found to reduce glucose levels, decrease AS-160 expression, and protect against streptozotacin, STZ, induced hyperglycemia. Additionally, OLE was found to maintain insulin levels within the normal range and similar to metformin treatment. These results suggest that OLE may have potential for use as an alternative to metformin treatment for diabetes. This article was authored by A.B.D. Alraman Al-Shutifat, Hadeel Al-Turk, Homs A.J. Alamir and others.