 The human immunodeficiency virus, HIV, can cause reduced immunity which can affect the effectiveness of vaccinations in people living with HIV, PLWH. Despite this, there have been few studies conducted into the effects of HIV on the efficacy of COVID-19 vaccines. Phase 3 clinical trials involving PLWH have been limited, and the safety and efficacy of these vaccines in PLWH remain unknown. And this article was authored by Tope Oilade, Rain Eyepenoma Raya and Kamaludin Latif.