 In agreement with the International Association for the Study of Pain, chronic pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. To date, there are several types of pain, nausiceptive, neuropathic, and nasoplastic. In the present narrative review, we evaluated the characteristics of the drugs used for each type of pain, according to guidelines, and their effects in people with comorbidity to reduce the development of severe adverse events. This article was authored by John Marco Marciano, Cristina Vaca, Maurizio Evangelista, and others.