 Cepsis is a life-threatening condition caused by an overwhelming immune response to infection. It is characterized by high levels of inflammatory cytokines and can lead to organ failure and death if not treated quickly. This study found that a specific type of RNA molecule called CERC-RNA-M SCAR is important for controlling the inflammatory response in Cepsis. The researchers developed a new method to deliver CERC-RNA-M SCAR directly to the mitochondria of macrophages, which are key players in the inflammatory process. When they did so, the inflammatory response was reduced and survival rates improved. This suggests that targeted delivery of CERC-RNA-M SCAR could be used to treat Cepsis. This article was authored by Li Fan, Li Yao, Zhilong Li, and others.