 Shift bases are aldehyde or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This short review compiles examples of the most promising antimalarial, antibacterial, antifungal, and antiviral shift bases. An overview of synthetic methodologies used for the preparation of shift bases is also described. This article was authored by Clayton M. De Silva, Daniel L. De Silva, Lucia V. Modelo, and others.