 The hardistonite-based, HT, bio-ceramic foams were easily obtained by heating silicon resins containing reactive oxides and calcium oxide fillers in air. The calcium oxide fillers provided the necessary calcium content while the reactive oxides provided the strontium and magnesium content needed to form the hardistonite structure. This structure had superior biocompatibility and bioactivity properties compared to pure hardistonite. Additionally, proteolytic-resistant adhesive peptide was selectively grafted onto the foams using two different strategies. One strategy involved protecting the peptide with a protective layer, but this approach was unsuccessful due to the acid sensitivity of the material. A new strategy involving aldehyde grafted peptide was developed which resulted in a significant increase in human osteoblast proliferation. Furthermore, no cytotoxicity was observed from the aldehyde grafted peptide. Finally, the functionalization process did not affect the cytotoxicity of the material. The functionalized foams exhibited increased expression of genes in coating bone. This article was authored by Ange Zemuner, Elena Zeni, Hamada El Sayed, and others. We are article.tv, links in the description below.