 Paclitaxal-loaded lipid-coated manganese ferrite magnetic nanoparticles, PTXLMNP, are a novel type of stimuli responsive drug delivery system designed to target melanoma cells while minimizing systemic toxicity and side effects. The particles can be administered intratumerally and then heated using a magnetic field, which causes them to release the drug locally and more effectively than other methods. This combination of chemotherapy and magnetic hypothermia has been shown to be highly effective in treating melanoma cells, resulting in higher efficacy and lower toxicity compared to traditional chemotherapy treatments. This article was authored by Relton R. Oliveira, Emilio Arcintra, Elton A. Souza Jr. and others.