 The current best way to achieve herd immunity from COVID-19 is through vaccination. Parents' willingness to vaccinate their children is key to achieving this goal. In this systematic review and meta-analysis, researchers found that the average global acceptance rate of parents to vaccinate their children with the COVID-19 vaccine is 57%. Factors such as parents' knowledge about the COVID-19 vaccine, trust in the vaccine, and accessibility of the vaccine were associated with higher acceptance rates. However, mental health issues such as worry and psychological distress were associated with lower acceptance rates. Governments and healthcare authorities should work to raise awareness about the benefits of the COVID-19 vaccine, provide easy access to the vaccine, and address any mental health concerns to ensure that parents are comfortable with vaccinating their children. This article was authored by Zaynab Alamiradi, Chunging Lin, and Amir H. Pakpor.