 This article reviews the formation, prevalence, affinity, and roles of IgE autoantibodies in autoimmunity, including their recent recognition as active drivers of autoimmunity through mechanisms involving type 1 interferons, basophil recruitment, and adaptive immune responses. The article also presents new evidence supporting that triggering of IgE receptors in plasma cytoid dendritic cells induces LC3-associated phagocytosis and potent B-cell differentiation. This article was authored by Rachel Ettinger, Jody Elcarno, Jill Hennaught, and others.