 Collagen is widely distributed in the human body and has been intensively studied as a biomaterial for tissue engineering applications, with various cross-linking methods and combinations explored to improve tissue function. Despite its advantages, sterilization of collagen remains challenging due to its protein structure. This review provides an overview of collagen-based biomaterials in tissue engineering, aimed at regenerative medicine use from lab to patient bedside. This article was authored by François Berthaud, Robert Govan, and Remy Parente-Barreil.