 The study investigates the complexities of cellular senescence, a state resulting from genotoxic injury that alters cellular metabolism and lysosomal activity. The secretory phenotype, SASP, produced by senescent cells has both beneficial and harmful effects on health. A meta-analysis of protein content in SASP obtained from different research groups was conducted, categorizing the data based on cell type, harmful agent, and senescent stage. Genontology and network analysis identified common and specific features of different senescent phenotypes, potentially paving the way for the development of new senopherapeutic drugs aimed at combating negative consequences associated with senescence. This article was authored by Yoho Gouma, Nicola Olesio, Domenico April, and others.