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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 4.1: Introduction and Molecular Recognition 01:18 Outline 02:15 Response time and sensitivity of sensors 03:33 The Spider Chart Of Sensors 05:17 A Matrix definition of selectivity 09:58 Classical approach to selectivity 12:55 Classical approach to selectivity 14:13 Selectivity classified 15:57 Outline 15:59 DNA binding and Salt screening 16:55 How does H2 stay together 17:50 Manning theory of DNA bonding 19:13 DNA binding energy: compact model 20:31 DNA binding energy: compact model 21:47 Parasitic binding to host site 22:36 Engineering DNA for better binding 24:15 Improved design of probes 25:35 Differential heating for parasitic desorption 26:30 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.