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nanoHUB-U Nanobiosensors L4.1: Selectivity - Introduction and Molecular Recognition

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Published on Feb 19, 2014

Table of Contents:
00:09 Lecture 4.1: Introduction and Molecular Recognition
01:18 Outline
02:15 Response time and sensitivity of sensors
03:33 The Spider Chart Of Sensors
05:17 A Matrix definition of selectivity
09:58 Classical approach to selectivity
12:55 Classical approach to selectivity
14:13 Selectivity classified
15:57 Outline
15:59 DNA binding and Salt screening
16:55 How does H2 stay together
17:50 Manning theory of DNA bonding
19:13 DNA binding energy: compact model
20:31 DNA binding energy: compact model
21:47 Parasitic binding to host site
22:36 Engineering DNA for better binding
24:15 Improved design of probes
25:35 Differential heating for parasitic desorption
26:30 Conclusions

This video is part of the nanoHUB-U course "Principles of Electronic Nanobiosensors". (https://nanohub.org/courses/PEN)

This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.

For more details see http://nanohub.org/u

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