 This study examined the risk factors associated with bleeding varicose veins, VVs, and chronic venous disease, CVD, patients. It was found that advanced clinical stage of CVD, C4B stage, advanced stage, living alone, suffering from cardiovascular comorbidity, hypertension and congestive heart failure, taking certain drugs that affect blood clotting, aspirin, anticoagulants, taking psychotropic medication, having specific venous reflex patterns, bologna GSV reflex, non-siphenous veins reflex, cockets perforators reflex, and not being evaluated and treated for CVD, with VADs, CT, or surgery, are all associated with a higher risk of bleeding VVs. These findings suggest that these risk factors should be taken into consideration when treating CVD patients to prevent potentially life-threatening bleeding VVs. This article was authored by Davide Costa, Nicola Olapi, Roberto Minasai, and others.