 The abstract summarizes the findings of a large-scale proteomic analysis of Alzheimer's disease brain tissues from multiple studies. The results suggest that proteins involved in synaptic function and vesicular transport are affected earlier in the disease progression, while those related to mitochondria are only affected later on. Additionally, certain brain regions are more susceptible to the disease than others. This article was authored by Manna Askenazi, Thomas Kavanaugh, Jeffrey Pires, and others.