 Analytical quality by design, AQBD, principles were used to develop and validate a rheology method for topical creams. Critical method variables, CMVs, such as sample application, peltier temperature control, and sample rest time were identified and a 23 full factorial design was applied to understand their impact on rotational, creep recovery and oscillatory measurements. The developed method was validated according to ICHQ2, R2, guidelines and demonstrated adequate precision, RSD less than 15%, and selectivity. This article was authored by Lucas Chiaranton, Caterina Cardoso, Margarita Miranda, and others.