 A robust biomedical informatics infrastructure is essential for academic health centers engaged in translational research. This infrastructure includes core components such as electronic data capture systems, electronic health records data repositories, and related tools, which are typically funded through a combination of fee for service, extramural grants, and institutional support. Additionally, regulatory systems, example, electronic institutional review board, IRB, systems, grants, and contracts, security systems, data warehouses, and clinical trials management systems are often supported by institutional funds. These findings highlight the importance of having a comprehensive informatics infrastructure in place to support translational research efforts. This article was authored by Jihad Essa Bade, Peter Tajahornok, Paul A. Harris, and others.