 This research paper discusses the use of engineered exosomes to deliver both a drug and a micro-RNA, myrna, to treat colorectal cancer, CRC. The myrna is designed to down-regulate the expression of the gene responsible for resistance to the drug, while the drug itself is used to kill the cancerous cells. This combination of therapies is effective at reversing the drug resistance and increasing the efficacy of the treatment. This article was authored by Ghafen Liang, Yang Liangzhu, Dula Thana said Jaffa Ali, and others.