 This study examined the genetic diversity and antimicrobial resistance of Salmonella enterica cerevartifi in Rwanda. Historical samples collected between 1984 and 1985 were compared to recent samples collected between 2010 and 2018. The results revealed that the majority of recent samples belonged to genotype 4.3.1.2, H58, which is resistant to antibiotics. This suggests that this strain may have been introduced into Rwanda from South Asia prior to 2010. Additionally, the study highlighted the need for improved transportation of molecular reagents and better computing infrastructure in order to make WGS more accessible in endemic settings. This article was authored by Jean-Pierre Ritangda, Tessa de Bloch, Vimal Quipers, and others.