 This study demonstrated a unique application of metal-assisted and microwave-accelerated evaporative crystallization, MAMAEC, technique for the decrystallization of uric acid crystals, which causes gout in humans. The technique uses metal nanoparticles, gold colloids, with low microwave heating to accelerate the decrystallization process and reduce the size and number of uric acid crystals by over 60% within 10 minutes. The use of gold colloids without microwave heating did not result in decrystallization, proving the utility of the MAMAEC technique for gout treatment. This article was authored by Bridget Kiyoko, Taiwo Ogunnally, Mornaiki Atabee, and others.