 The World Health Organization's, WHO, choosing interventions that are cost-effective, choice, program has been a leading force in the field of cost-effectiveness analysis for nearly two decades. Choice takes a generalized approach to cost-effectiveness analysis, which can be seen as a quantitative assessment of current and future efficiency within a health care system. This helps priorities resource allocation and ensure that health stewards have a clear understanding of where to allocate their resources to maximize health gains. Choice also offers a unique perspective on strategic planning, helping decision makers meet the goals outlined in the Sustainable Development Goals, SDGs. Over the last decade, Choice has updated its analytical framework and provided valuable insight into the cost-effectiveness of various interventions. This article was authored by Melanie Y. Bertram, Jeremy A. Lauer, Karen Stenberg, and others.