 The study found that the acceptability of HIV self-testing HIV-ST was high among students in Limpopo Province, South Africa. More women showed willingness to take up HIV-ST than men. Factors such as being sexually active, having multiple sexual partners and condom use during the last sexual encounter were associated with HIV-ST. This suggests that innovative demand creation strategies are needed to increase uptake of HIV-ST among students. This article was authored by Mimi Itefo, Samuel Elmzebel, and Mathilda M. Mockatel.