 Mesenchymal stromal progenitor slash stem cells, MSCs, are a rare population of non-hematopoietic stromal cells found in the bone marrow and other connective tissues. These cells can differentiate into bone, cartilage, fat, and muscle and are characterized by their expression of certain proteins such as CD90, CD105, and CD73, and lack of markers like CD34, CD45, and CD14. MSCs have the capacity to proliferate in culture while maintaining their multi-linage differentiation potential, making them attractive candidates for tissue repair approaches. However, the identity of these cells in their native tissues has yet to be determined, and their niche in the body remains unclear. This review discusses the current state of MSC research, including the differentiation potential of cultured MSCs, the expression of chemokines, and their receptors on MSCs, and the relationship between MSCs and parasites. Additionally, this review examines the need for further characterization of the endogenous MSC niches in their native.