 The Sentinel-2A multi-spectral instrument, MSI, has proven to be a valuable tool for geological remote sensing applications. It has been successfully used to detect minerals associated with a hydrothermal alteration system in southeast Spain. The results obtained with Sentinel-2A MSI were found to be highly correlated with those obtained using Landsat-8 operational land imager, OLI, and a simulated Sentinel-2A MSI dataset. Additionally, the resulting maps produced by Sentinel-2A MSI corresponded well with the conceptual geologic model of the epithermal deposit. This article was authored by Harold van der Woef and Freak van der Meer.