 A cluster of clade and monkeypox virus infections linked to sexual contact in the Democratic Republic of the Congo has been reported. With five reverse transcription PCR-confirmed infections and genome sequencing suggesting they belong to the same transmission chain, indicating thatpox transmission through sexual contact extends beyond clade IV. This article was authored by Emil M. Kibungu, Emmanuel H. Vakanyaki, Eddie Kingandalu Samaki, and others.