 Theoretical approaches have been instrumental in driving important scientific discoveries in biology, particularly in the areas of microbial growth and survival, cell physiology, host-pathogen interactions, and competitive or symbiotic interactions. Additionally, theory-based research has contributed novel, sometimes paradigm, shifting, findings in the fields of genome sequence analysis, climate change and planetary health, habitability, and astrobiology. Theoretical approaches have also played a key role in analyzing genome sequence data, developing techniques for practical experimentation or fieldwork, and providing insight into the intrinsic need for human engagement in scientific innovation. Furthermore, theoretical approaches have been used to explore the ways in which aspects of language can bias thinking toward the spatial rather than the temporal, leading to skewed scientific terminology. Additionally, the use of artificial intelligence technologies, such as chatbots, has raised concerns about the ethics of authorship and the potential for misleading results. Finally, theoretical approaches have been found to be essential in addressing the urgent research needs associated with the Covid-19 pandemic. This article was authored by John E. Halsworth, Tulema Udondo, Carlos Petrosalio, and others. We are article.tv, links in the description below.