 The study found that the expression of certain genes was altered when comparing freshly isolated primary MSCs to cultured MSCs. This suggests that the stem-ness properties of MSCs may change over time. Additionally, the study identified two distinct populations of bone marrow-derived stem cells, one that could reconstitute the hematopoietic microenvironment and another that could only produce bone tissue. This article was authored by Ping Zhong, Ji Dong, Xiaoying Fan, and others.