 This study investigated the expression level of defective in colon etylation one domain containing one oncogene in prostate cancer tissues compared to normal prostate tissues. It also examined the effects of this oncogene on prostate cancer cells in vitro. The results showed that the expression of the oncogene was significantly higher in prostate cancer tissues than in normal prostate tissues and it was associated with high score, metastasis and pathological stage. Furthermore, the oncogene was found to be an independent prognostic factor for disease free survival of prostate cancer patients. In vitro experiments revealed that the oncogene promoted proliferation, invasion and migration of prostate cancer cells. These findings suggest that the oncogene may play an important role in the development and progression of prostate cancer. This article was authored by Shun Tan Huan, Zeyzian Lu, Fooning Jiang and others.