 The abstract summarizes the main points of the paper, while the introduction provides background information about transdisciplinary research and community-based participatory research. The methods section explains the qualitative, convergent parallel case study design used to investigate how investigators from the Centers for Population Health and Health Disparities, CPHD, Initiative Integrated Transdisciplinary Team Science and Community Based Participatory Research, CBPR. The results section presents the findings from the interviews conducted with the CPHD investigators and staff. Finally, the conclusion section discusses the importance of combining principles of both transdisciplinary team science and CBPR to improve population health and increase health equity. This article was authored by Sarah D. Hall, Marion L. Newhouser, and Betty Thompson.