 The Clinical and Translational Science Award, CTSA, program hubs are uniquely positioned to facilitate interdisciplinary collaborations between academia and communities to address public health crises such as the opioid epidemic. At Columbia University's CTSA program hub, this process began with a university-wide planning and brainstorming phase to identify key leaders across many disciplines who were influential in addressing the opioid epidemic. This was followed by a campus-wide and community outreach to identify all interested parties. Finally, the hub provided targeted support for collaboration development, which resulted in interdisciplinary collaborations and grant funding. These efforts have been successful in developing and funding innovative interdisciplinary research, including the New York site of the Healing Communities Initiative. This article was authored by Jennifer L. Humensky, Zainab Abedin, Kortha Muhammad, and others.