 Venturia inequalis is the causal agent of apple scab, a devastating disease of apple. We outline several unique features of this pathogen, which are useful for molecular genetic studies intended to understand plant pathogen interactions. The pathogenicity mechanisms of the pathogen, an overview of apple defense responses, monogenic and polygenic resistance, and their utilization in scab resistance breeding programs are also reviewed. This article was authored by Gopalji Jha, Karnika Thaka and Priyanka Thaka.