 Illinois-8 is a pro-inflammatory cytokine that plays a key role in the development of several diseases such as psoriasis, acute respiratory distress syndrome, ARDS, chronic obstructive pulmonary disease, copped, rheumatoid arthritis, eye, and many cancers. Its expression is increased in these diseases and it is associated with disease severity. Illinois-8 also promotes angiogenesis, the growth of new blood vessels, which is important for tumor growth and metastasis. Therefore, blocking Illinois-8 signaling could be a potential therapeutic strategy for treating these diseases. This article was authored by Bazit Salim Khozi, Kaetang, and Asma Khozi.