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Integrin-Collagen binding interface, Rate My Science

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Uploaded on Nov 3, 2008

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Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 50% of the whole-body protein content.
The tropocollagen or "collagen molecule" is a subunit of larger collagen aggregates such as fibrils. It is approximately 300 nm long and 1.5 nm in diameter, made up of three polypeptide strands (called alpha peptides), each possessing the conformation of a left-handed helix (its name is not to be confused with the commonly occurring alpha helix, a right-handed structure). These three left-handed helices are twisted together into a right-handed coiled coil, a triple helix or "super helix", a cooperative quaternary structure stabilized by numerous hydrogen bonds.
Design & production: Kosi Gramatikoff, PhD & Robert Liddington, PhD

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