 This study examined the clinical and epidemiological profile of patients with chronic chagas disease in Sao Paulo, Brazil. The results showed that no significant differences were found between male and female patients except for the indeterminate form of the disease, which was more prevalent in males. Additionally, cardiac problems were the most commonly reported symptom, and functional class B1 was more common in females, whereas B2 was more prevalent in males. This suggests that late diagnosis of chagas disease may increase the risk of presenting digestive symptoms, but the classic manifestations of the disease and its comorbidities can be successfully managed if comprehensive multidisciplinary care is provided. This article was authored by Luiz Gonzaga Francisco de Assis-Barros de Liazanella, Isabella Walder-Galiano, Cinciaparineti Alves Martins, and others.