 This study compared the effects of three dietary supplements on gene expression in human peripheral blood mononuclear cells, PBMC krill oil, lean and fatty fish, and hyaluronic sunflower oil, HOSO, with added astaxanthin. The study found that krill oil had the most significant impact on gene expression, downregulating the expression of 13 genes related to glucose and cholesterol metabolism, beta-oxidation, and inflammation. Lean and fatty fish also showed some changes in gene expression, but these were less pronounced than those seen with krill oil. HOSO, with added astaxanthin, did not have any significant effect on gene expression. This article was authored by Amanda Rundblad, Kirstin B. Holvin, Ingebruheim, and others.