 The clinical sequencing evidence generating research consortium, CSER, conducted seven clinical genomic research projects involving diverse populations. The results showed that while only 18.7% of participants reported experiencing barriers to care, the case studies revealed a more complex picture that highlighted the blurred boundary between access to genomic research and clinical care. Based on these findings, we propose a broader definition of access to genomic medicine that includes multiple dimensions, such as financial, geographic, cultural, and linguistic access. Additionally, we suggest using mixed methods to study access issues, including surveys and qualitative case studies, and developing innovative improvement strategies to promote equitable, effective, and efficient access to genomic medicine. This article was authored by Amanda M. Gautiers, Jill O. Robinson, Simon M. Outram, and others.