 In advanced iron deficiency, note that the cytoplasmic maturation delay would have now affected a majority of cells. So the majority of cells are now going to start looking smaller than usual in addition to the variation of their sizes. Furthermore, the total amount of hemoglobin would now also diminish. So in advanced iron deficiency, you're going to see abnormalities in all the indices in contrast to early iron deficiency where the total hemoglobin may be within normal limits and the MCV may be within normal limits, but the variation in size would be abnormal.