 This meta-analysis compares the clinical outcomes of minimally invasive plating osteosynthesis, mypo, and other operative interventions in the treatment of humoral shaft fractures. The results suggest that both mypo and other operative interventions can achieve similar union time, ucla score, MEPI, and union rate. However, mypo is associated with better outcomes including shorter operation time and lower incidence of radial nerve injury. Evidence from this meta-analysis demonstrated that mypo is effective but safer than other operative interventions in the treatment of humoral shaft fracture. However, randomized controlled trials with larger sample sizes using appropriate blinding methods are needed to confirm these findings. This article was authored by Kwam Jong, Ning Sun, Chong Huang, and others.