 Single molecule electronic biosensors have been developed to detect biomolecules with high precision and accuracy. They provide detailed information about the molecular interactions and reactions that occur between biomolecules, which cannot be obtained through traditional methods. The sensors can measure the electrical signal generated by a single biomolecule, allowing researchers to study the behavior of individual molecules. Additionally, these sensors can be used to monitor the optical signal produced when light interacts with a single biomolecule, enabling researchers to observe the molecule's response to light. This article was authored by Xinyue Chang, Yanihua, Song Zhao, and others.