 Dietary polyphenol found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, and beverages have gained significant interest due to their potential chemo-preventive slash protective functions in maintaining human health and preventing chronic diseases such as neurodegenerative diseases, cardiovascular diseases, CVDs, cancer, diabetes, inflammatory disorders, and infectious illness. Increased intake of polyphenol-rich foods has been claimed to reduce oxidative cellular damage, DNA damage, tissue inflamations, viral slash bacterial infections, and neurodegenerative diseases through their powerful antioxidant activity, which plays a pivotal role in preventing OS-induced human diseases. This article was authored by Mithun Rudripal, Shubham J. Karnar, Jora Khan, and others.