 The epidermal growth factor receptor, EGFR, is a key regulator of cell physiology. It is activated by binding of its ligands, which triggers receptor dimerization, activation of kinase activity, and intracellular signaling. However, how this process is regulated at the molecular level has remained unclear. Using single particle tracking techniques, researchers have now identified that EGFR is confined within specific nanodomains when bound to its ligands. These nanodomains are composed of proteins such as clathrin and tetraspans, which can alter the receptor's ability to bind ligands. This suggests that EGFR's nanodomain structure plays a role in controlling its signaling pathway. This article was offered by Michael G. Sugiyama, Aidan I Brown, Jesus Vega-Lugo, and others.